Slick gene: Breeding sustainability through heat tolerance

High-producing dairy cows generate significant metabolic heat, making them vulnerable to hot and humid environments. Heat stress reduces milk yield, impairs fertility, and increases health problems, all of which negatively impact farm profitability and animal welfare. By introducing the Slick gene, dairy cattle can maintain higher productivity and reproductive performance under heat stress.

WHY ARE SLICK GENETICS IMPORTANT FOR PROFITABILITY AND SUSTAINABILITY?

From a global perspective, over 40% of the human population lives in the tropics, where heat and humidity are particularly hostile to high-producing dairy taurine cattle.

 Countries in these regions usually raise heat-tolerant and disease-resistant zebu cattle and their crosses with taurine cattle, but these animals are generally less productive.

As climate change intensifies, heat stress will become an even greater challenge worldwide.

Slick genetics offer a sustainable solution by reducing costs associated with cooling infrastructure, lowering water and energy use, and improving animal welfare.

In short, incorporating Slick genetics into breeding programs could enhance resilience and support food security while aligning with global sustainability goals.

The advantage of Slick genetics extends beyond dairy systems. For example, F1 Beef on Dairy calves inheriting the Slick gene are more resilient to heat challenges, reducing mortality and improving growth performance. This is especially important considering recent events such as the deaths of thousands of beef cattle in Kansas in 2022 and hundreds in Iowa in 2023, highlighting the economic and welfare risks associated with extreme heat.

 WHAT IS THE SLICK GENE AND HOW DOES IT IMPROVE HEAT TOLERANCE IN CATTLE?

 The “Slick gene” refers to specific variations in the DNA sequence of the Prolactin Receptor (PRLR) gene that produce the dominant “Slick” phenotype in cattle. This phenotype is characterized by animals having very short, sleek hair, which enhances their ability to dissipate heat and maintain thermal balance under hot and humid conditions. As a result, cattle carrying the Slick gene exhibit improved heat tolerance compared to animals with normal hair coats.

To date, researchers have identified six distinct Slick variants (SLICK1–SLICK6), each representing a different mutation in the PRLR gene. These variants were originally discovered in Creole cattle breeds from the Caribbean Basin, descended from Iberian cattle introduced during the colonization of the Americas.

The most widely studied variant, SLICK1, is commonly found in Senepol cattle, a breed well adapted to tropical environments. Following its discovery, the Slick gene has been introgressed into other breeds such as Holstein through crossbreeding and backcrossing programs.

The importance of such programs lies in the fact that resilience to heat stress is a complex trait in many cattle breeds, including Holsteins. Complex traits are influenced by a large number of genetic factors, each contributing a small effect, along with environmental influences. Although genomic selection has accelerated genetic progress for traits such as milk, fat, and protein yield over the past 15 years, SLICK1 transforms heat tolerance from a complex trait into a single-gene Mendelian trait, making it easier to select for and enabling even faster progress.

How Is STgenetics® Incorporating Slick Genetics Into Their Breeding Program?

The goal of the STgenetics® breeding program related to Slick genetics is to bring Slick into the modern genetic era. As dairies capitalize on advancements in Beef on Dairy, genomics, feed conversion efficiency, and increased fat and protein production, STgenetics® aims to apply Slick genetics without compromising these genetic gain initiatives.

The application of Slick genetics in our breeding program includes mating Slick carriers that are not as high in production or profit traits to the highest males or females in the population to increase the opportunity that the progeny will be a Slick carrier as well as improve production traits. Over time and multiple generations, we have established bloodlines of females and males through IVF technologies reducing generation intervals to see faster gains. 

Dr. Pete Hansen at the University of Florida made one of the largest steps in 2016 by bringing Slick-Gator Lone Ranger into the world. Lone Ranger has over 80 genomic tested sons and over 100 tested daughters. His contributions in components and health traits created the genetic building blocks of many of the pedigrees in Slick today. We still have opportunities to progress Slick genetics to increase production and profitability traits of Slick carriers to their full potential. 

The next step in Slick genetics is to create more homozygous Slick animals to ensure that their progeny will be Slick carriers. We currently have homozygous Slick bulls available in 4M™ semen and will continue to progress these genetics forward with the goal to make more heat tolerant and highly productive animals that will contribute to sustainable food production around the globe. 

HOW CAN I MANAGE SLICK GENETICS IN MY HERD?

Genetic Visions-ST™ provides Slick testing for females to screen your herd for Slick carriers.

These results can be viewed in STgenetics® STrategy™ platform and females can be a carrier, not a carrier or homozygous Slick.

Females can be sorted based on Slick carrier status to be mated to Slick bulls in Chromosomal Mating® to have the highest likelihood of Slick carrier status in progeny (see Figure 1). A Slick marker frequency chart can also be viewed in STrategy™ to track the frequency of the Slick marker in your herd over time. In Figure 2, the Slick marker frequency chart indicates that 13 females in the customer herd were carriers of the Slick1 marker out of 1101 females that were tested in 2024.

Slick genetics have the opportunity to make a positive impact on sustainable food production around the world by improving production performance in cattle, reducing water usage, and creating more resilient cattle in warm climates.

Located in Navasota, Texas, STgenetics® is making the world greener, more sustainable and profitable. By improving herd genetics through science and technology, we believe that the best way to predict the future is to create it, while feeding the world with our passion for the beef and dairy industries.

The STgenetics® Integrated Approach to management combines cutting edge genetics, innovation driven programs and gender-sorted semen to aid farmers in improving cattle performance to feed the world while reducing their carbon footprint.

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